Welcome to CUPdb!
Cuproptosis is a newly discovered form of cell death triggered by excessive copper accumulation. Copper ions target lipoylated TCA cycle proteins in the mitochondria, leading to the instability and aggregation of Fe-S cluster proteins, ultimately causing cell death. Cuproptosis is closely associated with the development and progression of various diseases, including cancer, cardiovascular diseases, and neurodegenerative diseases.[1]
CUPdb is a comprehensive database dedicated to cuproptosis research, designed to centralize scattered data and support in-depth studies in this field. It aggregates foundational information encompassing cuproptosis-related genes (CRGs), associated diseases, modulators, and key pathways. Building on this foundation, it features functional modules including a multi-dimensional modification atlas, prediction of upstream modification regulatory axes, CRG-centric tumor co-dependency networks, pathway localization, and upstream/downstream gene networks, facilitating the exploration of cuproptosis mechanisms.
