The following data table shows the top 100 highly Top Co-dependencies genes after the was knocked out by CRISPR-Cas9 technology. The figure shows the genes with a correlation greater than 0.4 or the top 30 genes with a correlation, which are presented according to the distribution of GO clusters associated with cuproptosis. Genes related with cuproptosis in our database are marked in Blue green.
The following data table shows the top 100 highly Top Co-dependencies genes after the was knocked out by CRISPR-Cas9 technology.Cuproptosis related genes are the ones included in our database.Co-dependent gene's GO Term means that the gene is present under the cuproptosis related GO Term of our interest. The larger the value of correlation, the stronger the correlation or co-dependence between the two genes.The presence of others GO indicated that the gene was not one of the cuproptosis related go in our study.
Cuproptosis Gene | Co-dependencies Gene | Co-dependencies Gene GO Term | Correlation |
---|---|---|---|
FDX1 | ACAD9 | others GO | 0.33782329082789 |
FDX1 | BCS1L | others GO | 0.37472496258244 |
FDX1 | COA5 | others GO | 0.35846325115911 |
FDX1 | COA6 | mitochondrial ATP synthesis coupled electron transport | 0.35417582963684 |
FDX1 | COA6 | copper ion binding | 0.35417582963684 |
FDX1 | COA6 | plasma membrane ATP synthesis coupled electron transport | 0.35417582963684 |
FDX1 | COA7 | others GO | 0.32517943869275 |
FDX1 | COQ2 | others GO | 0.3588617384007 |
FDX1 | COQ4 | others GO | 0.40618409916739 |
FDX1 | COX10 | aerobic respiration | 0.32881760613971 |
FDX1 | COX10 | copper ion homeostasis | 0.32881760613971 |
FDX1 | COX14 | others GO | 0.32819327342025 |
FDX1 | COX16 | others GO | 0.35223074407695 |
FDX1 | COX4I1 | mitochondrial electron transport, cytochrome c to oxygen | 0.37929342955455 |
FDX1 | COX4I1 | cellular respiration | 0.37929342955455 |
FDX1 | COX5B | cellular respiration | 0.38349362788905 |
FDX1 | COX5B | mitochondrial electron transport, cytochrome c to oxygen | 0.38349362788905 |
FDX1 | COX6B1 | mitochondrial electron transport, cytochrome c to oxygen | 0.34252583650002 |
FDX1 | COX6B1 | cellular respiration | 0.34252583650002 |
FDX1 | COX6C | mitochondrial electron transport, cytochrome c to oxygen | 0.36842944440453 |
FDX1 | COX6C | cellular respiration | 0.36842944440453 |
FDX1 | CYC1 | mitochondrial electron transport, ubiquinol to cytochrome c | 0.39811846390807 |
FDX1 | CYC1 | cellular respiration | 0.39811846390807 |
FDX1 | DAP3 | others GO | 0.32965732931432 |
FDX1 | DARS2 | others GO | 0.32779570193076 |
FDX1 | DLD | pyruvate metabolic process | 0.48713489215979 |
FDX1 | DLD | mitochondrial electron transport, NADH to ubiquinone | 0.48713489215979 |
FDX1 | DLST | tricarboxylic acid cycle | 0.34371159175782 |
FDX1 | DMAC1 | others GO | 0.33211747090105 |
FDX1 | ECSIT | others GO | 0.3618100852306 |
FDX1 | FARS2 | others GO | 0.3289645672208 |
FDX1 | FASTKD5 | others GO | 0.38301353193036 |
FDX1 | FH | tricarboxylic acid cycle | 0.32335559178538 |
FDX1 | FOXRED1 | others GO | 0.37523832822411 |
FDX1 | GATC | others GO | 0.31381270116859 |
FDX1 | GCSH | protein lipoylation | 0.42156162378981 |
FDX1 | GLRX5 | iron-sulfur cluster assembly | 0.46394199759979 |
FDX1 | GTPBP8 | others GO | 0.32590916406214 |
FDX1 | HARS2 | others GO | 0.31687920067155 |
FDX1 | HCCS | respiratory electron transport chain | 0.37098256328063 |
FDX1 | IBA57 | iron-sulfur cluster assembly | 0.33939718269597 |
FDX1 | ISCA1 | iron-sulfur cluster assembly | 0.3912800166617 |
FDX1 | ISCA2 | others GO | 0.45322251808309 |
FDX1 | LIAS | lipoate synthase activity | 0.51375412620415 |
FDX1 | LIAS | response to oxidative stress | 0.51375412620415 |
FDX1 | LIAS | lipoate biosynthetic process | 0.51375412620415 |
FDX1 | LIAS | protein lipoylation | 0.51375412620415 |
FDX1 | LIPT1 | protein lipoylation | 0.44301973379663 |
FDX1 | LRPPRC | others GO | 0.33742414264632 |
FDX1 | MRPL13 | others GO | 0.34885020436082 |
FDX1 | MRPL17 | others GO | 0.32095382755057 |
FDX1 | MRPL21 | others GO | 0.32128796812332 |
FDX1 | MRPL22 | others GO | 0.32751631862941 |
FDX1 | MRPS16 | others GO | 0.36128311561667 |
FDX1 | MRPS17 | others GO | 0.34220748327543 |
FDX1 | MRPS18B | others GO | 0.31400454297355 |
FDX1 | MRPS2 | others GO | 0.33541745791693 |
FDX1 | MRPS24 | others GO | 0.33997657899263 |
FDX1 | MRPS25 | others GO | 0.32121972377218 |
FDX1 | MRPS33 | others GO | 0.33909398131464 |
FDX1 | MRPS6 | others GO | 0.35107275036759 |
FDX1 | MTG1 | others GO | 0.33559600368893 |
FDX1 | NARS2 | others GO | 0.33925938518542 |
FDX1 | NDUFA1 | proton motive force-driven mitochondrial ATP synthesis | 0.3818182667315 |
FDX1 | NDUFA1 | aerobic respiration | 0.3818182667315 |
FDX1 | NDUFA1 | mitochondrial electron transport, NADH to ubiquinone | 0.3818182667315 |
FDX1 | NDUFA10 | proton motive force-driven mitochondrial ATP synthesis | 0.35318683836722 |
FDX1 | NDUFA10 | aerobic respiration | 0.35318683836722 |
FDX1 | NDUFA10 | mitochondrial electron transport, NADH to ubiquinone | 0.35318683836722 |
FDX1 | NDUFA11 | aerobic respiration | 0.36750705320471 |
FDX1 | NDUFA11 | proton motive force-driven mitochondrial ATP synthesis | 0.36750705320471 |
FDX1 | NDUFA2 | proton motive force-driven mitochondrial ATP synthesis | 0.3749097398019 |
FDX1 | NDUFA2 | aerobic respiration | 0.3749097398019 |
FDX1 | NDUFA2 | mitochondrial electron transport, NADH to ubiquinone | 0.3749097398019 |
FDX1 | NDUFA6 | response to oxidative stress | 0.38334939566571 |
FDX1 | NDUFA6 | proton motive force-driven mitochondrial ATP synthesis | 0.38334939566571 |
FDX1 | NDUFA6 | aerobic respiration | 0.38334939566571 |
FDX1 | NDUFA6 | mitochondrial electron transport, NADH to ubiquinone | 0.38334939566571 |
FDX1 | NDUFA8 | mitochondrial electron transport, NADH to ubiquinone | 0.33164791327283 |
FDX1 | NDUFA8 | proton motive force-driven mitochondrial ATP synthesis | 0.33164791327283 |
FDX1 | NDUFA8 | aerobic respiration | 0.33164791327283 |
FDX1 | NDUFA9 | mitochondrial electron transport, NADH to ubiquinone | 0.36329763635954 |
FDX1 | NDUFA9 | proton motive force-driven mitochondrial ATP synthesis | 0.36329763635954 |
FDX1 | NDUFA9 | aerobic respiration | 0.36329763635954 |
FDX1 | NDUFAF3 | others GO | 0.32360846858989 |
FDX1 | NDUFAF4 | others GO | 0.3417496880862 |
FDX1 | NDUFAF7 | others GO | 0.36243589322287 |
FDX1 | NDUFB10 | mitochondrial electron transport, NADH to ubiquinone | 0.43182646083211 |
FDX1 | NDUFB10 | aerobic respiration | 0.43182646083211 |
FDX1 | NDUFB10 | proton motive force-driven mitochondrial ATP synthesis | 0.43182646083211 |
FDX1 | NDUFB11 | aerobic respiration | 0.34580673067065 |
FDX1 | NDUFB11 | proton motive force-driven mitochondrial ATP synthesis | 0.34580673067065 |
FDX1 | NDUFB2 | aerobic respiration | 0.37575508192746 |
FDX1 | NDUFB2 | proton motive force-driven mitochondrial ATP synthesis | 0.37575508192746 |
FDX1 | NDUFB2 | mitochondrial electron transport, NADH to ubiquinone | 0.37575508192746 |
FDX1 | NDUFB3 | aerobic respiration | 0.37151847241304 |
FDX1 | NDUFB3 | proton motive force-driven mitochondrial ATP synthesis | 0.37151847241304 |
FDX1 | NDUFB3 | mitochondrial electron transport, NADH to ubiquinone | 0.37151847241304 |
FDX1 | NDUFB4 | mitochondrial electron transport, NADH to ubiquinone | 0.36938161930936 |
FDX1 | NDUFB4 | proton motive force-driven mitochondrial ATP synthesis | 0.36938161930936 |
FDX1 | NDUFB4 | aerobic respiration | 0.36938161930936 |
FDX1 | NDUFB5 | mitochondrial electron transport, NADH to ubiquinone | 0.39183334375043 |
FDX1 | NDUFB5 | aerobic respiration | 0.39183334375043 |
FDX1 | NDUFB5 | proton motive force-driven mitochondrial ATP synthesis | 0.39183334375043 |
FDX1 | NDUFB6 | proton motive force-driven mitochondrial ATP synthesis | 0.35430302087347 |
FDX1 | NDUFB6 | mitochondrial ATP synthesis coupled electron transport | 0.35430302087347 |
FDX1 | NDUFB6 | aerobic respiration | 0.35430302087347 |
FDX1 | NDUFB6 | mitochondrial electron transport, NADH to ubiquinone | 0.35430302087347 |
FDX1 | NDUFB8 | mitochondrial electron transport, NADH to ubiquinone | 0.42004231037296 |
FDX1 | NDUFB8 | proton motive force-driven mitochondrial ATP synthesis | 0.42004231037296 |
FDX1 | NDUFB8 | aerobic respiration | 0.42004231037296 |
FDX1 | NDUFB9 | proton motive force-driven mitochondrial ATP synthesis | 0.33262479527394 |
FDX1 | NDUFB9 | aerobic respiration | 0.33262479527394 |
FDX1 | NDUFB9 | mitochondrial electron transport, NADH to ubiquinone | 0.33262479527394 |
FDX1 | NDUFC1 | mitochondrial electron transport, NADH to ubiquinone | 0.38291258406202 |
FDX1 | NDUFC1 | proton motive force-driven mitochondrial ATP synthesis | 0.38291258406202 |
FDX1 | NDUFC1 | aerobic respiration | 0.38291258406202 |
FDX1 | NDUFC2 | mitochondrial electron transport, NADH to ubiquinone | 0.34560504511327 |
FDX1 | NDUFC2 | aerobic respiration | 0.34560504511327 |
FDX1 | NDUFC2 | proton motive force-driven mitochondrial ATP synthesis | 0.34560504511327 |
FDX1 | NDUFS1 | cellular respiration | 0.40491430200584 |
FDX1 | NDUFS1 | aerobic respiration | 0.40491430200584 |
FDX1 | NDUFS1 | proton motive force-driven mitochondrial ATP synthesis | 0.40491430200584 |
FDX1 | NDUFS1 | mitochondrial electron transport, NADH to ubiquinone | 0.40491430200584 |
FDX1 | NDUFS2 | proton motive force-driven mitochondrial ATP synthesis | 0.34701305462717 |
FDX1 | NDUFS2 | mitochondrial electron transport, NADH to ubiquinone | 0.34701305462717 |
FDX1 | NDUFS2 | mitochondrial ATP synthesis coupled electron transport | 0.34701305462717 |
FDX1 | NDUFS2 | aerobic respiration | 0.34701305462717 |
FDX1 | NDUFS3 | aerobic respiration | 0.34093564042187 |
FDX1 | NDUFS3 | proton motive force-driven mitochondrial ATP synthesis | 0.34093564042187 |
FDX1 | NDUFS3 | mitochondrial electron transport, NADH to ubiquinone | 0.34093564042187 |
FDX1 | NDUFS5 | aerobic respiration | 0.34459291285638 |
FDX1 | NDUFS5 | proton motive force-driven mitochondrial ATP synthesis | 0.34459291285638 |
FDX1 | NDUFS5 | mitochondrial electron transport, NADH to ubiquinone | 0.34459291285638 |
FDX1 | NDUFS7 | aerobic respiration | 0.39182039488452 |
FDX1 | NDUFS7 | mitochondrial electron transport, NADH to ubiquinone | 0.39182039488452 |
FDX1 | NDUFS7 | proton motive force-driven mitochondrial ATP synthesis | 0.39182039488452 |
FDX1 | NDUFS8 | proton motive force-driven mitochondrial ATP synthesis | 0.34517753669706 |
FDX1 | NDUFS8 | aerobic respiration | 0.34517753669706 |
FDX1 | NDUFS8 | mitochondrial electron transport, NADH to ubiquinone | 0.34517753669706 |
FDX1 | NDUFV1 | proton motive force-driven mitochondrial ATP synthesis | 0.36519549552226 |
FDX1 | NDUFV1 | mitochondrial ATP synthesis coupled electron transport | 0.36519549552226 |
FDX1 | NDUFV1 | aerobic respiration | 0.36519549552226 |
FDX1 | NDUFV1 | mitochondrial electron transport, NADH to ubiquinone | 0.36519549552226 |
FDX1 | NDUFV2 | mitochondrial electron transport, NADH to ubiquinone | 0.37122688806501 |
FDX1 | NDUFV2 | proton motive force-driven mitochondrial ATP synthesis | 0.37122688806501 |
FDX1 | NDUFV2 | aerobic respiration | 0.37122688806501 |
FDX1 | NFU1 | others GO | 0.40118653768173 |
FDX1 | PDSS1 | others GO | 0.39510352229459 |
FDX1 | PET117 | others GO | 0.37059470921915 |
FDX1 | QRSL1 | others GO | 0.31941353853656 |
FDX1 | RBFA | others GO | 0.31655397351885 |
FDX1 | SCO1 | intracellular copper ion homeostasis | 0.32300922617 |
FDX1 | SCO1 | copper ion binding | 0.32300922617 |
FDX1 | SCO2 | intracellular copper ion homeostasis | 0.32326151383548 |
FDX1 | SCO2 | copper ion binding | 0.32326151383548 |
FDX1 | SCO2 | respiratory electron transport chain | 0.32326151383548 |
FDX1 | SDHA | mitochondrial electron transport, succinate to ubiquinone | 0.35336554440278 |
FDX1 | SDHA | respiratory electron transport chain | 0.35336554440278 |
FDX1 | SDHA | proton motive force-driven mitochondrial ATP synthesis | 0.35336554440278 |
FDX1 | SDHA | tricarboxylic acid cycle | 0.35336554440278 |
FDX1 | SDHB | proton motive force-driven mitochondrial ATP synthesis | 0.37199113932309 |
FDX1 | SDHB | respiratory electron transport chain | 0.37199113932309 |
FDX1 | SDHB | tricarboxylic acid cycle | 0.37199113932309 |
FDX1 | SDHB | mitochondrial electron transport, succinate to ubiquinone | 0.37199113932309 |
FDX1 | SDHB | aerobic respiration | 0.37199113932309 |
FDX1 | SLC25A19 | others GO | 0.31993508940264 |
FDX1 | SLC25A26 | others GO | 0.37700859483751 |
FDX1 | SSBP1 | others GO | 0.3214062864897 |
FDX1 | TIMMDC1 | others GO | 0.38405932537095 |
FDX1 | TPK1 | others GO | 0.30334921832753 |
FDX1 | TRUB2 | others GO | 0.33450531334136 |
FDX1 | UQCR10 | cellular respiration | 0.34778934871508 |
FDX1 | UQCR10 | mitochondrial electron transport, ubiquinol to cytochrome c | 0.34778934871508 |
FDX1 | UQCRB | oxidative phosphorylation | 0.39462002736627 |
FDX1 | UQCRB | cellular respiration | 0.39462002736627 |
FDX1 | UQCRB | aerobic respiration | 0.39462002736627 |
FDX1 | UQCRB | mitochondrial electron transport, ubiquinol to cytochrome c | 0.39462002736627 |
FDX1 | UQCRC1 | cellular respiration | 0.43632665396027 |
FDX1 | UQCRC1 | aerobic respiration | 0.43632665396027 |
FDX1 | UQCRC1 | mitochondrial electron transport, ubiquinol to cytochrome c | 0.43632665396027 |
FDX1 | UQCRC1 | oxidative phosphorylation | 0.43632665396027 |
FDX1 | UQCRC2 | cellular respiration | 0.39978119297543 |
FDX1 | UQCRC2 | oxidative phosphorylation | 0.39978119297543 |
FDX1 | UQCRC2 | aerobic respiration | 0.39978119297543 |
FDX1 | UQCRC2 | mitochondrial electron transport, ubiquinol to cytochrome c | 0.39978119297543 |
FDX1 | UQCRFS1 | mitochondrial electron transport, ubiquinol to cytochrome c | 0.35307956979032 |
FDX1 | UQCRFS1 | respiratory electron transport chain | 0.35307956979032 |