♥ The major role of snoRNA is guiding RNA modifications of snRNA or rRNA. Generally, Box C/D (box C: TGATGA and box D: CTGA) snoRNAs guide 2'O-methylation of target RNAs, while Box H/ACA (box H: ANANNA and box ACA: ACA) snoRNAs guide pseudouridylation. Specially, scaRNAs with both box C/D and box H/ACA guide snRNA modifications transcripted by RNA polymerase II.

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