Diagnosis Model
Key genes with potential influence on the development of NADC among PLWH
Compared to the general population, the vast majority (30/40) of NADCs showed increased standardized incidence rates (SIR) in PLWH. "dNADC" was developed to explore the potential diagnostic biomarkers for NADC. Key gene features, defined as dysregulated expressed genes (DEGs) in both PLWH and cancer patients, alongside the upstream regulatory factors within the HIV DEGs, were employed to construct the diagnostic model using RF and CIT. 10-fold cross-validation showed an accuracy of more than 80% in 13 out of 16 cancer types.
Performance of dNADC in BLCA after HIV infection with ART Therapy
Key genes of BLCA after HIV infection with ART Therapy
PPI network of key genes
Connectivity map of key genes