Risk Assessment Model
Key indicators with potential risk for the occurrence of NADC among PLWH
Given that three main theories including immunosuppression, chronic inflammation and oncogenic pathways, NADCdb systematically identified a set of pivotal factors with specific dysregulation for KIRC and BRCA. A risk assessment model named "rNADC" was constructed by deciphering the normal expression profiles and their regulatory biological pathways, which achieved an impressive accuracy of 85.7% in an external validation cohort. A tool with the same name (also known as rNADC) has also been developed to assess the risk degree of NADC development in PLWH according to the uploaded genes or factors.
Risk assessment factors of KIRC after HIV infection
PPI network of risk assessment factors
Connectivity map of risk assessment factors